The Argentine player thumped No. 20, Croatia’s Borna Coric, in straight sets Sunday night in his first Round of 16 match. Del Potro won, 6-4, 6-3, 6-1 to move on to the quarter finals of the 2018 US Open.
Del Potro will play in the quarter-finals for a third straight year and sixth time overall, reaching the last eight without dropping a set.
Del Potro has won seven of 11 prior matches with Isner, including a straight-sets victory in the fourth round of the French Open this year. He won the US Open in Flushing Meadows in 2009.
He will take on American John Isner for a semi-final spot. Isner, seeded 11th, defeated Canadian Milos Raonic in a battle of big-servers 3-6, 6-3, 6-4, 3-6, 6-2.